COMPETITIVE INHIBITION OF HYDROXYLAMINE ON ALCOHOL DEHYDROGENASE
نویسندگان
چکیده
منابع مشابه
Inhibition effects of furfural on alcohol dehydrogenase, aldehyde dehydrogenase and pyruvate dehydrogenase.
The kinetics of furfural inhibition of the enzymes alcohol dehydrogenase (ADH; EC 1.1.1.1), aldehyde dehydrogenase (AlDH; EC 1.2.1.5) and the pyruvate dehydrogenase (PDH) complex were studied in vitro. At a concentration of less than 2 mM furfural was found to decrease the activity of both PDH and AlDH by more than 90%, whereas the ADH activity decreased by less than 20% at the same concentrati...
متن کاملInhibition of hepatic alcohol dehydrogenase by bilirubin.
Human bile is capable of inhibiting, in vitro, the action of human and equine liver alcohol dehydrogenase. The effect is attributable mainly to bilirubin conjugates. Sodium deoxycholate had negligible inhibitory ability. Preliminary evidence indicates that the mechanism of this inhibition of alcohol dehydrogenase is related to the capability of bilirubin for complex formation with the zinc ion....
متن کاملDrosophila melanogaster alcohol dehydrogenase: product-inhibition studies.
The Drosophila melanogaster alleloenzymes AdhS and AdhF have been studied with respect to product inhibition by using the two substrate couples propan-2-ol/acetone and ethanol/acetaldehyde together with the coenzyme couple NAD+/NADH. With both substrate couples the reaction was consistent with an ordered Bi Bi mechanism. The substrates added to the enzyme in a compulsory order, with coenzyme as...
متن کاملHydroxylamine Inhibition of Xanthine Oxidase
In the course of investigations regarding the effects of various chemical agents on neoplast,ic purine metabolism, it was observed that hydroxylamine prevents the accumulation of uric acid or allantoin that normally occurs upon incubation of crude tissue homogenates. Subsequent studies, reported in this paper, demonstrate that hydroxylamine is a competitive inhibitor of xanthine oxidase activit...
متن کاملIn Vitro Inhibition Studies of Human Class II Alcohol Dehydrogenase
Alcohol dehydrogenase (ADH) is an enzyme in the human body that processes the alcohol concentration in the blood. Alcohol dehydrogenase is a dimer which means it’s a molecule that consists of two parts which are called monomers. There are seven different dehydrogenases. ADH can be found in many organisms and it facilitates the oxidisation of alcohols to aldehydes or ketones and at the same time...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1953
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)66235-0